Béla Novák
Béla is a world leader in mathematical modelling of the cell cycle based in the Department of Biochemistry at the University of Oxford.
We have worked with Béla to gain completely new insights into S-phase entry and the roles of intrinsic DNA damage in mediating proliferation-quiescence decisions. We're continuing this productive collaboration in our work at Imperial to expand our current models and integrate additional signalling pathways.
Tony Ly
Tony is pioneering new proteomics approaches for analysing cell cycle state transitions. He is a Sir Henry Dale Fellow, funded by the Wellcome Trust and The Royal Society, at the Centre for Gene Regulation at the University of Dundee.
With Tony, we are investigating how quiescence induced by intrinsic DNA damage is regulated to maintain genome stability.
Pau Creixell
Pau is a team leader at the CRUK Cambridge Institute. He is an expert in computational systems biology, with an interest in how kinases achieve substrate specificity to drive specific cellular phenotypes.
With Pau, we are investigating how different tyrosine kinases control cell cycle entry.
Philipp Thomas
Philipp is a Lecturer in the Department of Mathematics at Imperial. His research develops stochastic methods to understand single-cell dynamics and cell-to-cell variability in biological populations. He is particularly interested in the coupling of stochastic gene expression with the cell cycle.
With Philipp, we are investigating the causes and consequences of cellular heterogeneity for cancer cell growth and proliferation.
Maria Secrier
Maria is a cancer bioinformatician and a UKRI FLF in the Department of Genetics at UCL. She shares our interest in cancer cell quiescence - how it arises, how it is maintained and the consequences for patients. With Maria we are working out cancer cell quiescence leads to poor outcomes in Non-Small Cell Lung Cancer and how mechanisms that drive breast cancer cell quiescence can help to maintain tumour dormancy.
Anna Barnard
Anna is a chemist with expertise in peptide synthesis and optimisation to disrupt protein-protein interactions and better treat human disease. She is a Wellcome Trust Sir Henry Dale Fellows in the Institute of Chemical Biology in the Department of Chemistry at Imperial.
We are working with Anna’s team to develop novel stapled peptides to disrupt protein-protein interactions in the cell cycle to more efficiently eliminate cancer cells.
